PlantImRecepV1, Main, Exploration, bibRecord, 000088

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease.

Identifieur interne : 000088 ( Main/Exploration ); précédent : 000087; suivant : 000089

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease.

Auteurs : Carmen Ciavarella [Italie] ; Ilenia Motta [Italie] ; Sabrina Valente [Italie] ; Gianandrea Pasquinelli [Italie]

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2020.

RBID : pubmed:32365556

Descripteurs français

KwdFr :
- Animaux (MeSH), Cytokines (antagonistes et inhibiteurs), Huiles de poisson (pharmacologie), Humains (MeSH), Infections à coronavirus (anatomopathologie), Infections à coronavirus (immunologie), Infections à coronavirus (traitement médicamenteux), Ligands (MeSH), Pandémies (MeSH), Plantes médicinales (composition chimique), Pneumopathie virale (anatomopathologie), Pneumopathie virale (immunologie), Pneumopathie virale (traitement médicamenteux), Produits de la mer (analyse), Récepteur PPAR gamma (agonistes), Thiazolidinediones (pharmacologie), Épices (analyse).
MESH :
- agonistes : Récepteur PPAR gamma.
- analyse : Produits de la mer, Épices.
- anatomopathologie : Infections à coronavirus, Pneumopathie virale.
- antagonistes et inhibiteurs : Cytokines.
- composition chimique : Plantes médicinales.
- immunologie : Infections à coronavirus, Pneumopathie virale.
- pharmacologie : Huiles de poisson, Thiazolidinediones.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- Animaux, Humains, Ligands, Pandémies.

English descriptors

KwdEn :
- Animals (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (immunology), Coronavirus Infections (pathology), Cytokines (antagonists & inhibitors), Fish Oils (pharmacology), Humans (MeSH), Ligands (MeSH), PPAR gamma (agonists), Pandemics (MeSH), Plants, Medicinal (chemistry), Pneumonia, Viral (drug therapy), Pneumonia, Viral (immunology), Pneumonia, Viral (pathology), Seafood (analysis), Spices (analysis), Thiazolidinediones (pharmacology).
MESH :
- chemical , agonists : PPAR gamma.
- chemical , antagonists & inhibitors : Cytokines.
- analysis : Seafood, Spices.
- chemistry : Plants, Medicinal.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- pathology : Coronavirus Infections, Pneumonia, Viral.
- chemical , pharmacology : Fish Oils, Thiazolidinediones.
- Animals, Humans, Ligands, Pandemics.

Abstract

The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-γ, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-γ also represses the inflammatory process. Similarly, the PPAR-γ agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-γ, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-γ activation. Here, we review the main synthetic and nutritional PPAR-γ ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.

DOI: 10.3390/molecules25092076
PubMed: 32365556
PubMed Central: PMC7248959

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000144
to stream Main, to step Curation: 000144

Le document en format XML

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<front><div type="abstract" xml:lang="en">The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-γ, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-γ also represses the inflammatory process. Similarly, the PPAR-γ agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-γ, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-γ activation. Here, we review the main synthetic and nutritional PPAR-γ ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.</div>
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Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease.

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease.

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